Institute of Biophysics, Chinese Academy of Sciences: chymotrypsin is expected to be used for hepatitis B prevention December 24, 2018 Source: China Science News Author: Wang Fei Recently, He Rongqiao, a researcher at the Institute of Biophysics of the Chinese Academy of Sciences, studied the role of lumbrokinase isoenzyme (LKI) in the fight against hepatitis B. One of the isozymes was observed for hepatitis B core antigen (HBeAg). High activity. The researchers said that the isoenzyme is hepatitis B core antigen protease (HBeAgase), and its degradation site is on the linear epitope of interaction between HBeAg molecule and T lymphocyte, and it can also reduce HBeAg secreted by HepG2.2.15 cells. The work was published in the Chinese Life Sciences. 蚯蚓 is an annelid, living in the soil, they are the natural cultivators of the soil. Due to its unique biological properties, alfalfa is widely used in biochemistry, pharmacology, environmental science, toxicology, food science, agricultural science and technology. As a drug, sputum is increasingly used in basic and clinical research. It has been reported that sputum can synthesize a group of protease molecules, which can be used to treat certain cardiovascular and cerebrovascular diseases, diabetes, kidney disease, cirrhosis and other diseases. At present, there are relatively many studies on the pharmacological mechanisms of chymotrypsin anti-thrombosis and inhibition of organ fibrosis. In terms of antithrombotic action, chymotrypsin has an activity of degrading fibrinogen and fibrin, and also inhibiting platelet aggregation. Chymotrypsin has the activity of tissue plasminogen activator (tPA) and is therefore called 蚓 kinase (LK) by Japanese scientists. LKI has been studied and applied in the intervention of cerebral thrombosis and myocardial infarction. In inhibiting organ fibrosis, LKI has a role in reducing molecules such as fibronectin, collagen, and laminin. Therefore, LKI has potential application value in pulmonary fibrosis, renal fibrosis and liver fibrosis. "The reason why chymotrypsin can be widely used is based on their relatively broad substrate specificity. Moreover, these protease molecules can change the conformation of the active site by the induction of the substrate, thereby improving the selection of the substrate. Sex." He Rongqiao introduced. He believes that 蚯蚓 bears the dual pressures of the environment and heredity, which makes the enzyme molecules produced by sputum have a wide substrate specificity to adapt to changes in their living environment. The results published recently will provide the basis for further research on the prevention and treatment of hepatitis B in LKI. Ammonium Acetate,Acetate Ammonium,Acetic Acid Ammonium Salt,Ammonium Ethanoate Wuxi Yangshan Biochemical Co.,Ltd. , https://www.salesacetates.com